Shortening of Interpupillary Distance after Instillation of Topical Prostaglandin Eye Drops
上記論文非常に興味深い。ルミガンを点すと85％以上の人に眼幅の2ミリ以上の短縮を認める。タプロスが一番影響が少ない（17.2％）。以下この論文の要旨。
私の名前も入れていただき、佐野一矢先生、高橋秀徳先生にはこの場を借りてお礼申し上げます。
ICHIYA SANO, HIDENORI TAKAHASHI, SATORU INODA, SHINICHI SAKAMOTO, YUSUKE ARAI, YUJI TAKAHASHI, AKIRA OHKUBO, HIDETOSHI KAWASHIMA, AND CHIHIRO MAYAMA
PURPOSE: To investigate changes in the interpupillary distance (IPD) after continual instillation of topical pros- taglandin analogs (PGAs) in glaucoma patients as an objective indicator of prostaglandin-associated periorbit- opathy (PAP).
DESIGN: Retrospective, comparative case series.
METHODS: A total of 152 institutional patients with glaucoma were enrolled in this study. Inclusion criteria were visual acuities exceeding 10/20 bilaterally and no intraocular surgery during observation. INTERVENTION/ OBSERVATION PROCEDURES: First-time bilateral instillation of bimatoprost, travoprost, latanoprost, or tafluprost and IPDs measured by automatic refractometry. IPDs, intra- ocular pressures (IOPs), and refractive errors were measured before and after continual drug administration (treatment, 2-24 months). MAIN OUTCOME MEASURE- MENTS: Post-treatment changes in IPDs. A total of 61 un- treated patients served as controls.
RESULTS: The IPDs shortened significantly (P < 0.001) after treatment (L0.80 ± 2.1 mm); the IPDs of control subjects remained unchanged (0.05 ± 0.96 mm; P [ 0.69). The IPD change after bimatoprost instillation (L2.20 ± 0.97 mm) was significantly (P < 0.001) greater than with other PGAs (L0.65 ± 2.09 mm). The IOPs decreased significantly (P < 0.001) (L3.7 ± 4.3 mm Hg); the refractive errors did not change signif- icantly (P < 0.099) (L0.07 ± 0.69 diopter) post- treatment. The percentages of subjects with 2-mm or greater decreases in IPD after bimatoprost, travoprost, latanoprost, or tafluprost were 85.7%, 20.0%, 18.2%, and 17.2%, respectively, and with 3-mm or greater de- creases in IPD 35.7%, 12.0%, 14.5%, and 12.1%, respectively. The specificities were 93.4% and 100% in the control group, respectively, with IPD threshold changes of 2 and 3 mm or more, respectively.
SUBJECTS: The medical records of patients with glau- coma at the Jichi Medical University Hospital, JCHO Tokyo Shinjuku Medical Center, Takahashi Eye Clinic
と当院での患者さんのデータも反映されている。
私の名前も入れていただき、佐野一矢先生、高橋秀徳先生にはこの場を借りてお礼申し上げます。
ICHIYA SANO, HIDENORI TAKAHASHI, SATORU INODA, SHINICHI SAKAMOTO, YUSUKE ARAI, YUJI TAKAHASHI, AKIRA OHKUBO, HIDETOSHI KAWASHIMA, AND CHIHIRO MAYAMA
PURPOSE: To investigate changes in the interpupillary distance (IPD) after continual instillation of topical pros- taglandin analogs (PGAs) in glaucoma patients as an objective indicator of prostaglandin-associated periorbit- opathy (PAP).
DESIGN: Retrospective, comparative case series.
METHODS: A total of 152 institutional patients with glaucoma were enrolled in this study. Inclusion criteria were visual acuities exceeding 10/20 bilaterally and no intraocular surgery during observation. INTERVENTION/ OBSERVATION PROCEDURES: First-time bilateral instillation of bimatoprost, travoprost, latanoprost, or tafluprost and IPDs measured by automatic refractometry. IPDs, intra- ocular pressures (IOPs), and refractive errors were measured before and after continual drug administration (treatment, 2-24 months). MAIN OUTCOME MEASURE- MENTS: Post-treatment changes in IPDs. A total of 61 un- treated patients served as controls.
RESULTS: The IPDs shortened significantly (P < 0.001) after treatment (L0.80 ± 2.1 mm); the IPDs of control subjects remained unchanged (0.05 ± 0.96 mm; P [ 0.69). The IPD change after bimatoprost instillation (L2.20 ± 0.97 mm) was significantly (P < 0.001) greater than with other PGAs (L0.65 ± 2.09 mm). The IOPs decreased significantly (P < 0.001) (L3.7 ± 4.3 mm Hg); the refractive errors did not change signif- icantly (P < 0.099) (L0.07 ± 0.69 diopter) post- treatment. The percentages of subjects with 2-mm or greater decreases in IPD after bimatoprost, travoprost, latanoprost, or tafluprost were 85.7%, 20.0%, 18.2%, and 17.2%, respectively, and with 3-mm or greater de- creases in IPD 35.7%, 12.0%, 14.5%, and 12.1%, respectively. The specificities were 93.4% and 100% in the control group, respectively, with IPD threshold changes of 2 and 3 mm or more, respectively.
SUBJECTS: The medical records of patients with glau- coma at the Jichi Medical University Hospital, JCHO Tokyo Shinjuku Medical Center, Takahashi Eye Clinic
と当院での患者さんのデータも反映されている。
2020-02-14 14:13
nice!(0)